Knowledge-guided fuzzy logic modeling to infer cellular signaling networks from proteomic data
نویسندگان
چکیده
منابع مشابه
Knowledge-guided fuzzy logic modeling to infer cellular signaling networks from proteomic data
Modeling of signaling pathways is crucial for understanding and predicting cellular responses to drug treatments. However, canonical signaling pathways curated from literature are seldom context-specific and thus can hardly predict cell type-specific response to external perturbations; purely data-driven methods also have drawbacks such as limited biological interpretability. Therefore, hybrid ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep35652